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Alternatives Assessment Guidance

As defined in the OECD Meta-Review, a chemical substitution or alternatives assessment framework is an arrangement of analyses and decisions that can be used to assess alternatives. A number of organizations have developed frameworks and guides in response to regulations of chemical substances and stakeholder interest in having consistent approaches to evaluate alternatives. Frameworks differ in terms of the attributes addressed and the methodologies used. The frameworks listed below are the most prominent.


TURI Alternatives Assessment

TURI conducted an assessment of alternatives to five chemicals of concern - lead, formaldehyde, perchloroethylene, hexavalent chromium, and di (2-ethylhexyl) phthalate (DEHP) -  in 2006.  As part of this seminal work, we created guidance for the process. 

US Environmental Protection Agency: Design for the Environment (DfE)

EPA uses alternatives assessments to look for safer chemicals. Design for the Environment (DfE) alternatives assessments are conducted as risk management actions when warranted for TSCA Work Plan Chemicals. They have also been conducted under Chemical Action Plans

Interstate Chemicals Clearinghouse (IC2)

The Interstate Chemicals Clearinghouse (IC2) is an association of state, local, and tribal governments that promotes a clean environment, healthy communities, and a vital economy through the development and use of safer chemicals and products. The IC2 is a collaboration between multiple US States interested in promoting the use of Alternatives Assessment as the preferred method for creating a safer chemicals economy.  The IC2 Alternatives Assessment Guide is designed to enable standardization of the alternatives assessment process.  

The Organization for Economic Cooperation and Development (OECD) Toolbox

This toolbox is a compilation of resources relevant to chemical substitution and alternatives assessments.