The U.S. Occupational Safety and Health Administration (OSHA) and U.S. EPA regulate MDI.
- The OSHA permissible exposure limit (PEL) for MDI is 0.02 ppm and should not be exceeded at any time.
The U.S. EPA regulates MDI under the authority of three environmental statutes. Under the:
- Clean Air Act, MDI is a "hazardous air pollutant."
- Comprehensive Environmental Responsibility, Compensation and Liability Act (popularly known as "'Superfund"), MDI is a "hazardous substance."
- Emergency Planning and Community Right-to-Know Act, TRI program, all large quantity users of MDI must submit data on environmental releases and off-site transfers.
For related information, see the Toxics Use Reduction Institute Formaldehyde and Toluene Diisocyanates Chemical Fact Sheets.