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Manufacturers use dimethylformamide as a solvent in a variety of applications, including the production of electronic components, pharmaceutical products, textile coatings, and urethanes. 

Human studies have identified increased rates of testicular cancer in humans exposed to DMF.  Animal studies have documented teratogenic effects, including decreased fetal weight and increased spontaneous abortions. A human study of individuals exposed to multiple chemicals suggests that DMF may increase the rate of spontaneous abortions.

Dimethylformamide is designated as a Higher Hazard Substance under TURA, which lowers the reporting threshold to 1,000 lb/year, effective January 2016.

Information about Dimethylformamide Prepared by the TURA Program

Content Category Publication Type Title Year Description
Overview Fact Sheet Dimethylformamide Fact Sheet 2003 TURI Chemical Fact Sheets describe the hazards, exposure routes, uses and alternatives, and regulatory context for selected chemicals.
Policy Policy Analysis Dimethylformamide Policy Analysis 2014 TURA Policy Analyses are developed as background for state-level decision-making about individual chemicals, chemical classes, and industry sectors.