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Toluene Diioscyanates

Toluene-2,6-diisocyanate (2,6-TDI), toluene-2,4-diisocyanate (2,4-TDI), and toluene diisocyanate mixed isomers are the three forms of TDI commonly used in commerce. Exposure to TDIs can result in severe skin, eye, lung, and throat irritation, and respiratory sensitization. TDIs are strong sensitizers and are classified as possible carcinogens. Workplaces are the primary source of exposure to TDIs. TDI’s are used as intermediary chemicals in the manufacture of polyurethanes, among other applications. In Massachusetts, businesses used 6.6 million pounds of TDIs in 2014.

Toluene Diisocyanates are designated as a Higher Hazard Substance under TURA, which lowers the reporting threshold to 1,000 lb/year, effective January 2017.

Information about Toluene Diisocyanates Prepared by the TURA Program 

Content Category Publication Type Title Year Description
Overview Fact Sheet Toluene Diisocyantes Fact Sheet 2016 TURI Chemical Fact Sheets describe the hazards, exposure routes, uses and alternatives, and regulatory context for selected chemicals.
Policy Policy  Analysis Toluene Diisocyanates Policy Analysis 2014 TURA Policy Analyses are developed as background for state wide decision making about individual chemicals and chemical classes.

Other Resources

Source Title Year Description
Agency for Toxic Substances and Disease Registry Toxicological Profile for TDI 2011 The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described.
EPA Action Plan for TDI 2011 Information about TDI and related EPA activities
NIOSH Toluene Diisocyanate (TDI) and Toluenediamine: Evidence of Carcinogenicity 2014 Chemical and physical properties, exposure limits, studies of carcinogenicity.
California Office of Environmental Health Hazards Toluene Diisocyanates (2,4 and 2,6) 2016 Overview of Reference Exposure Levels (RELs)