December 7, 2010

Science Advisory Board Meeting Minutes

December 7, 2010

Mass DEP: 2nd Floor

1 PM

Members Present: Dave Williams, Larry Boise, Martha Mittelstaedt, Veronica Vieira, Hilary Hackbart, Robin Dodson

Others Present: Heather Tenney (TURI), Carol Rowan West (DEP), John Raschko (OTA), Liz Harriman (TURI), Glenn Keith (DEP), Jennifer Nash (NU)

Welcome and Introductions

Program Updates

● A draft of the TURA 20th anniversary brochure was circulated.

● There are 16 new chemicals to be added to TRI. A copy of the final rule with the 16 chemicals listed was circulated.

● An update was given on the OTA barriers report on asthmagens.

● A tip sheet on household cleaners was circulated.

● The Decision Making Document was circulated and an update was given on plans for the final minor changes.

● An update was given on the implementation plan for TCE so the Board could get a sense of the program activities that occur after a HHS has been designated.

October Meeting Minutes

Approved with edits clarifying:

● the comments of the presenter (Dr. Bob Golden)

● the expected written outcome of the NAS review

● comments regarding the DEP presentation

Higher Hazard Substance Alternatives: VMSs

The group reviewed the data sheets that Mary had prepared on HMDS and D5 as a preliminary review to determine whether they should be listed under TURA. Also, this was the group’s first review of the new format of the data sheets. Overall feedback on the data sheets was positive. One comment is to change roman numeral references to numbers. The Board identified items to obtain prior to making a decision on the VMSs.

D5

● Carcinogenicity was the primary concern noted for D5 - uterine tumors/endometrial carcinomas were observed by inhalation.

● Obtain the referenced study (Lassen et al.) and look to see if there are additional studies regarding carcinogenicity.

● Bioaccumulation is also a concern. There is an EPA chemical action plan for D4 and D5 – look into when it will be complete.

● Look for neurotoxicity information at Cal OEHA.

● Look into the basis (health effect) for the Dow exposure limits (respiratory or dermal). ● Check to see if NIOSH or ACGIH have begun any action.

● Is there an EPA DFE dry cleaning update?

● Do d3, d6 exist? D5 is not estrogenic, D4 is.

● It was noted that the threshold would be regular a TURA threshold unless it was designated a HHS.

HMDS

● There was concern with flammability for HMDS. The flashpoint/flammability information needs to be clarified. There was a question about temperature listed as 125 degrees C.

● The possibility of HMDS being water reactive was questioned. It was suggested that it is more likely that water affects its effectiveness.

● It was noted that Acetone was listed for flammability alone.

● TURI will get flashpoints for all VMSs (especially linear VMSs OS20, OS30).

● Obtain the IARC/Carcinogenicity information for all as well.

● The BCF is high.

● Double check PBT data for all Os’s.

● Inquire about the basis for the Dow TWA of 200 (endpoint, study).

TURI will obtain this additional information for HMDS and D5 to discuss further next time.

Formaldehyde Update

A bibliography of all the formaldehyde information the Board has received thus far was handed out so Members will know what is available if it is needed again. The NTP Draft Report on Carcinogens Substance Report on Formaldehyde (June 2010) and the widely referenced Hauptmann et al 2004 ( Mortality from Solid Cancers among Workers in Formaldehyde Industries) were handed out as well. TURI will follow the NAS process so the Board can be prepared to move forward when the process is complete.

Higher Hazard Substance Alternatives: d-limonene

There were some questions regarding how the d-limonene is derived (naturally versus synthetically), whether that is discernable, and whether it makes a difference in toxicity. It is possible that naturally derived d-limonene is not as hazardous as synthetically derived. It was questioned whether d-limonene is GRAS (Generally Recognized as Safe by FDA) and if so if there is GRAS data. German data shows it as a skin sensitizer.

● Obtain the IARC monograph to see why it was classified as a Group 3.

● Obtain the 1990 NTP study.

● Get more info on fate and transport on aldehydes breakdown products and small particles (aerosols).

● Look into its ozone depletion potential.

● Get Finish exposure limits – what health effect, why.

● Scorecard source for neurotoxocity and other organ toxicity

● It was questioned why it works as a pesticide?

TURI will obtain this additional information for d-limonene to discuss further next time.

Adjourn

Next Meeting Date: Tuesday 1/11/11