December 9, 2008

Toxics Use Reduction Institute Science Advisory Board Meeting Minutes
December 9, 2008

Members Present: Dave Williams, Larry Boise, Chris Swartz, Lorraine Braunsdorf, Veronica Vieira

Others Present: Heather Tenney (TURI), John Raschko (OTA), Liz Harriman (TURI), Glenn Keith (DEP)

Welcome and Introductions

Program Updates

• Governor's Report has been completed; Heather will email it.

• John updated on the significant OTA cuts; 9 staff were lost

• 2009 is 20th anniversary of Program - event planned (NIOSH grant sought)

• Chemical list regs (including CERCLA and PCE) are to be finalized this month

• Liz, John and Glenn updated on the 11/5 Advisory Committee and the 11/19 Administrative Council meeting

November Meeting Minutes
John Raschko suggested clarifications to the Lead and Mercury in Concrete petition wording. Minutes were approved with this change.

14 CERCLA Chemicals Review

Ammonium bicarbonate
Mutagenicity studies were all negative
Low toxicity
GRAS
Unanimous vote to Delist

Ferrous Chloride, Ferrous Sulfate, Ferric Chloride, Ferric Sulfate
GRAS
Many negative studies, few positive mutagenicity studies
The positive mutagenicity tests were uncompelling (confounding factors: Arochlor/magnetic field/studied individuals predisposed to iron sensitivity)
Still 2 articles pending
DEP issue with these chems was LD50's
LD50 51 mg/kg FeSO4
Somnolence, Respiratory depression
Unanimous vote to Delist

Aluminum Sulfate (ALUM)
Concerns with worker hazard, drives pH and can go caustic very quickly
Workers exposed in waste water treatment, potential for splash
Neurological effects from environmental exposure
Positive mutagenicity data and reproductive effects
Schedule for stakeholder meeting

Adipic Acid
GRAS
Error in RTECS, no positive mutagenicity studies, 53 negative
Mutagenicity data gap was filled
Hilary recommends delisting
Persistence in air not a concern
LD50 high
Unanimous vote to Delist

Maleic Acid, Fumaric Acid
Hilary and Heather welcome additional Members review of mutagenicity studies
Review at January Meeting

Amyl Acetate, Butyl Acetate, isobutyl Acetate
All mutagenicity studies are negative
Ethyl acetate was retained in past delisting
Ethyl acetate most potent, butyl-mid, amyl- least
All have flammability issues
IDLH of concern; Amyl Acetate is lowest at 1000 ppm
Concern in environment, vapor phase in ground
2 negative neurotox studies on amyl
1 positive neurotox study on butyl, short term effects
Butyl Acetate: 59 negative mutagenicity studies, some reproductive effects
Unanimous vote to Delist Amyl
Schedule Butyl Acetate and isobutyl Acetate for stakeholder meeting

Ammonium Chloride
Some low LD50s in non-oral routes
1 positive mutagenicity test (still pending), 2 negative
High oral LD50
DEP Concerns - persistent in air, lack of tox data
Decision - table to review positive mutagenicity study
Review at January Meeting

Ammonium Sulfamate
Confirm whether it is an indirect food additive; for use only as component of adhesives.
No Mutagenicity data available
Historic use as an herbicide
Schedule for stakeholder meeting

Next Meeting Jan 7th - 3 tabled chemicals; Lead and Mercury in Concrete