References

November 2021

References for Quaternary Ammonium Compounds Fact Sheet

[1]United States Environmental Protection Agency, List N: Disinfectants for Use Against SARS-CoV-2 (COVID-19): https://cfpub.epa.gov/wizards/disinfectants/

[2] Vereshchagin, A.N.; Frolov, N.A.; Egorova, K.S.; Seitkalieva, M.M.; Ananikov, V.P. Quaternary Ammonium Compounds (QACs) and Ionic Liquids (ILs) as Biocides: From Simple Antiseptics to Tunable Antimicrobials. Int. J. Mol. Sci. 202122, 6793. https://doi.org/10.3390/ijms22136793

[3] USEPA/Office of Pesticide Programs; Didecyl Dimethyl Ammonium Chloride (DDAC) Final Work Plan, Registration Review: Initial Docket Case Number 3003, March 2017. Docket Number EPA-HQ-OPP-2015-0740

[4] United States Environmental Protection Agency (2017) Alkyls Dimethyl Benzyl Ammonium Chloride (ADBAC) Final Work Plan, Registration Review: Initial Docket, Case Number 03050, Docket Number EPA-HQ-OPP-2015-0737.

[5] ECHA; Didecyldimethylammonium chloride (7173-51-5). Registered Data Dossier. Helsinki, Finland: European Chemicals Agency. Accessed at: https://echa.europa.eu/registration-dossier/-/registereddossier/5864/4/2

[6] ECHA; Didecyldimethylammonium chloride (7173-51-5). Registered Data Dossier. Helsinki, Finland: European Chemicals Agency. Accessed at: https://echa.europa.eu/registration-dossier/-/registereddossier/5864/4/2

[7] Stepan Company, Stepanquat 8358: https://zh.stepan.com/content/stepan-dot-com/en/products-markets/product/STEPANQUAT8358.html

[8] Global Antiseptics And Disinfectants Market Report, 2021-2028 (grandviewresearch.com)

[9] Quinn MM, Henneberger PK, Braun B, Delclos GL, Fagan K, Huang V, et al. Cleaning and disinfecting environmental surfaces in health care: toward an integrated framework for infection and occupational illness prevention. Am J Infect Control. 2015;43:424–34.

[10] Vandenplas, O., D’Alpaos, V., Evrard, G., Jamart, J.,Thimpont, J., Huaux, F., Renauld, J., (2013) Asthma related to cleaning agents: a clinical insight. British Medical Journal  (http://dx.doi.org/10.1136/

bmjopen-2013-003568

[11] Preller L, Doekes G, Heederik D, Vermeulen R, Vogelzang PF, Boleij JS. Disinfectant use as a risk factor for atopic sensitization and symptoms consistent with asthma: an epidemiological study. Eur Respir J. 1996 Jul;9(7):1407-13. doi: 10.1183/09031936.96.09071407. PMID: 8836651.

[12] Dumas O, Boggs KM, Quinot C, Varraso R, Zock JP, Henneberger PK, Speizer FE, Le Moual N, Camargo CA Jr. Occupational exposure to disinfectants and asthma incidence in U.S. nurses: A prospective cohort study. Am J Ind Med. 2020 Jan;63(1):44-50. doi: 10.1002/ajim.23067. Epub 2019 Nov 6. PMID: 31692020; PMCID: PMC6891131.

[13] Bernstein, Jonathan, et al (1994) A combined respiratory and cutaneous hypersensitivity syndrome induced by work exposure to quaternary amines. Journal of Allergy and Clinical Immunology

[14] Association of Occupational and Environmental Clinics (AOEC) Exposure code lookup for Didecyl Dimethyl Ammonium Chloride (CAS 7173-51-5) accessed on 8/17/20: http://www.aoecdata.org/ExpCodeLookup.aspx

[15] Association of Occupational and Environmental Clinics (AOEC) Exposure code lookup for Alkyl Dimethylbenzyl ammonium chloride (CAS #: 68424-85-1) accessed on 10/14/20: http://www.aoecdata.org/ExpCodeLookup.aspx

[16] Dumas O, Varraso R, Boggs KM, et al. Association of Occupational Exposure to Disinfectants With Incidence of Chronic Obstructive Pulmonary Disease Among US Female Nurses. JAMA Netw Open. 2019;2(10):e1913563. doi:10.1001/jamanetworkopen.2019.13563

[17] Dumas O, Boggs KM, Quinot C, Varraso R, Zock JP, Henneberger PK, Speizer FE, Le Moual N, Camargo CA Jr. Occupational exposure to disinfectants and asthma incidence in U.S. nurses: A prospective cohort study. Am J Ind Med. 2020 Jan;63(1):44-50. doi: 10.1002/ajim.23067. Epub 2019 Nov 6. PMID: 31692020; PMCID: PMC6891131.

[18] Gonzalez M, Jégu J, Kopferschmitt MC, Donnay C, Hedelin G, Matzinger F, Velten M, Guilloux L, Cantineau A, de Blay F. Asthma among workers in healthcare settings: role of disinfection with quaternary ammonium compounds. Clin Exp Allergy. 2014 Mar;44(3):393-406. doi: 10.1111/cea.12215. PMID: 24128009.

[19] Anderson, S. E., Shane, H., Long, C., Lukomska, E., Meade, B. J., & Marshall, N. B. (2016). Evaluation of the irritancy and hypersensitivity potential following topical application of didecyldimethylammonium chloride. Journal of Immunotoxicology13(4), 557–566. https://doi-org.umasslowell.idm.oclc.org/10.3109/1547691X.2016.1140854

[20] Melin, V. E., Potineni, H., Hunt, P., Griswold, J., Siems, B., Werre, S. R., & Hrubec, T. C. (2014). Exposure to common quaternary ammonium disinfectants decreases fertility in mice. Reproductive Toxicology50, 163–170. https://doi-org.umasslowell.idm.oclc.org/10.1016/j.reprotox.2014.07.071

[21] Melin, V. E., Melin, T. E., Dessify, B. J., Nguyen, C. T., Shea, C. S., & Hrubec, T. C. (2016). Quaternary ammonium disinfectants cause subfertility in mice by targeting both male and female reproductive processes. Reproductive Toxicology (Elmsford, N.Y.)59, 159–166. https://doi-org.umasslowell.idm.oclc.org/10.1016/j.reprotox.2015.10.006

[22] Hrubec TC, Melin VE, Shea CS, et al. Ambient and Dosed Exposure to Quaternary Ammonium Disinfectants Causes Neural Tube Defects in Rodents. Birth Defects Res. 2017;109(14):1166-1178. doi:10.1002/bdr2.1064

[23] Melin, V. E., Potineni, H., Hunt, P., Griswold, J., Siems, B., Werre, S. R., & Hrubec, T. C. (2014). Exposure to common quaternary ammonium disinfectants decreases fertility in mice. Reproductive Toxicology, 50, 163–170. https://doi-org.umasslowell.idm.oclc.org/10.1016/j.reprotox.2014.07.071

[24] Melin VE, Melin TE, Dessify BJ, Nguyen CT, Shea CS, Hrubec TC. Quaternary ammonium disinfectants cause subfertility in mice by targeting both male and female reproductive processes. Reprod Toxicol. 2016 Jan;59:159-66. doi: 10.1016/j.reprotox.2015.10.006. Epub 2015 Nov 12. PMID: 26582257

[25] Hrubec TC, Melin VE, Shea CS, et al. Ambient and Dosed Exposure to Quaternary Ammonium Disinfectants Causes Neural Tube Defects in Rodents. Birth Defects Res. 2017;109(14):1166-1178. doi:10.1002/bdr2.1064

[26] Hrubec TC, et al. (2020) Altered Toxicological Endpoints in Humans with Quaternary Ammonium Compound Exposure doi: https://doi.org/10.1101/2020.07.15.20154963

[27] Herron, J.; Reese, R. C.; Tallman, K. A.; Narayanaswamy, R.; Porter, N. A.; Xu, L., Identification of environmental quaternary ammonium compounds as direct inhibitors of cholesterol biosynthesis. Toxicol. Sci. 2016, 151, 261-270.

[28] Datta, S.; He, G.; Tomilov, A.; Sahdeo, S.; Denison, M. S.; Cortopassi, G., In vitro evaluation of mitochondrial function and estrogen signaling in cell lines exposed to the antiseptic cetylpyridinium chloride. Environ. Health Perspect. 2017, 125, 087015-087015.

[29] Guomao Zheng, Gabriel M. Filippelli, and Amina Salamova Increased Indoor Exposure to Commonly Used Disinfectant during the COVID-19 Pandemic, Environmental Science & Technology Letters 2020 7 (10), 760-765 DOI: 10.1021/acs.estlett.0c00587

[30] https://www.epa.gov/pesticide-labels/dfe-certified-disinfectants

[31] Association of Occupational and Environmental Clinics (AOEC) Exposure Code 050.480 “Mixture of Hydrogen Peroxide and Peroxyacetic Acid” Accessed 9/21/2021: http://www.aoecdata.org/ExpCodeLookup.aspx

[32] https://www.turi.org/content/download/11795/186838/file/Decision-making%20under%20TURA%20-%20October%202018.pdf